Nih swiss mice

Sep 30, 1986 · Male NIH Swiss mice exhibited a macrocytic-megaloblastic anemia following inhalation of 1250 ppm BD for 6 weeks. 3, 05, 0. 70 to 5. 7). Jan 1, 2011 · Four strains of mice (BALB/c, NIH Swiss, C3H/HeN, and C57BL/6) were selected based on their different intrinsic radiation sensitivities as demonstrated by varying LD 50/30 (the dose that causes death in half of exposed mice within 30 days). After 14 d, the animals were intracerebrally challenged with a virulent strain of Bordetella pertussis ATCC 18323 (0. A relatively wide range of breeding ages was used to increase the likelihood that the results could be applied broadly rather than restricted to a narrow age group. Both immune sera had high titers of antibodies detectable in radioimmune precipitation assays using [3H]leucine-labeled AKR virus and in radioimmunoassays using purified virion components. 5Gy) resulted in significant protection to radiation-induced mortality and DNA damage in blood leukocytes. Cryan and colleagues have tried another approach: feeding mice different types of bacteria. A review of spontaneous bone and joint lesions in female aging NIH Black Swiss mice (Cr:NIH BL[S]) revealed a high incidence of fibro-osseous lesions (FOL; 89%) and degenerative joint lesions (90%). S. Dietary bisphenol A (BPA) was evaluated in a mouse two-generation study at 0, 0. Plasma levels of caffeine in the chronically treated mice range from 0. The modifying effects of the aqueous extract of saffron (dried stigmas of Crocus sativus Linn. Apr 1, 2017 · Abstract. 03 ml/dose of a bacterial suspension of 10 IOU/ml diluted 1/3,000). The experimental design included four groups of S. Method : One week after surgery, each OVX mouse was housed under one of 4 social conditions: (1) isolated, (2) accompanied by an intact Though in clinical use for many years, the anxiolytic activity of Pulsatilla nigricans (Puls) has not been evaluated experimentally. /d) in male Swiss mice induced significant hepatic DNA damage which was observed using the alkaline comet assay and equally altered hematological and clinical biochemical parameters. In total, 2270 Sprague-Dawley rats and 852 Swiss mice were included in these three studies. Sep 1, 2005 · These findings indicate that NIH Swiss and Black Swiss mice are visually im paired and thus may be unsuitable for use in some experiments. During this time mice were housed 1-3 per cage and were fed ad lib with standard chow (Tekland Global 18% Pretein Rodent Diet). 00 a. Materials and methods: Mature male Swiss mice were divided into 6 Jun 29, 2010 · Animals. 9. 2 ± 0. Dec 18, 2020 · Our study sought to establish values to serve as reference values in various hematological and biochemical of serum parameters in mice of the Swiss (heterogeneous), BALB/c and C57BL/6 (isogenic) and B6D2F1 (hybrid) lineages, to guide researchers in the best choice of an experimental model. 8, 38-44 cM). The mice were acclimatized for 7 days before treatment onset. Hence the present study was conducted in Swiss albino mice to evaluate the anxiolytic activity of Puls and compare its activity with the standard anxiolytic drug, diazepam. When the bold NIH Swiss mice received BALB/c gut bacteria, they hesitated about three times longer than normal before stepping down . All mice, which were purchased through the National Cancer Institute (NCI), were male, 8 weeks old Aug 1, 2013 · The forced swim test (FST) is a preclinical test to the screening of antidepressants based on rats or mice behaviours, which is also sensitive to stimulants of motor activity. pyrethrum. Group treatment is carried out by giving a combination of pellets and soybeans. In serum of HgCl2 treated mice there was significant elevation in serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT Mar 14, 2020 · Fifteen male Swiss albino mice (31. The effect of S. Cancer Res. They were housed in polyurethane While administration of midazolam at 40 min post-TETS injection terminated persistent seizures in almost all (≥95%) mice in our study, one NIH Swiss mouse continued to seize for ≥80 min after treatment with midazolam for a total SE duration ≥120 min. The several sublines of so-called Swiss mice in the United States derive from two males and seven females obtained for the Rockefeller Institute in 1926 by Clara Lynch from Andre de Coulon in Jun 21, 2018 · Comprehensive histological assessment revealed elevated microglia/macrophage reactivity and a moderate increase in astrogliosis in Swiss Webster that was associated with reduced microcavity formation and reduced lesion volume after spinal cord transection compared to C57BL/6 mice. Apr 12, 2021 · The third study (BT 6010) was performed on Swiss mice, used five dose levels, and again began dosing prenatally . We would like to show you a description here but the site won’t allow us. However, silibinin treatment after irradiation was not as effective as pre-administration. Eighty mice developed a total of 110 neoplasms by 5 months of age. A type-C RNA virus has been isolated that replicates readily in human and other primate cells. ), and submitted to behavioral tests. Alkaline Phosphatase. To this end, mice were administered with crude extracts (500 mg/kg, p. Sep 3, 2020 · Adult healthy male Swiss Albino mice with weights in the range of 25–30 g were housed in polypropylene cages under standard lighting (12 h day/night cycle) and relative humidity (50 ± 15%) conditions in temperature-controlled rooms (22 ± 1 °C) as previously described (Aboul-Soud et al. A detailed characterization of the NTCU model is needed. Gastrointestinal microbiota were assessed using denaturing gradient gel electrophoresis and sequencing. Toxicity of Apigenin is however, least explored, and reports are scanty in literature. 001), AST (P<0. mansoni - infected mice; without treatment (controls), curcumin-treated, Praziquantel (PZQ)-treated, and PZQ +curcumin treated mice … The developmental NOAEL was 3 mg/kg/day BAC. Animals were provided with standard diet (pellets) supplied by Amrut feed India and water was given ad libitum. into 145 neonatal NIH Swiss [N:NIH (s)] mice. Methods: Five groups of male (total n = 457) and five groups female (total n = 396) Swiss mice were treated from 12 days of gestation through the lifespan with sucralose in their feed at concentrations of 0, 500 Abstract. The widespread use of this species can be attributed to the mouse's high fertility rate, short gestation period, small size, ease of maintenance, susceptibility or resistance to different infectious agents, and Apr 4, 2003 · Animals. Aug 30, 2017 · This article reports 1- and 4-week 1,2-DCE-inhalation studies on the male reproductive systems of National Institutes of Health (NIH) Swiss mice. HgCl2 (5. In these studies, adult male NIH Swiss mice were surgically implanted with radiotelemetry probes that simultaneously monitored core temperature and locomotor activity across various housing conditions. Female BALB/cJ, C57BL/6J (B6), and Swiss Webster (SW) mice that were 6 to 18 wk at the start of the study were used. were examined. 7 and 1. 01) with a significant reduction in liver weight (P<0. Materials and methods: Mice were divided into two groups, BLM-treated and normal control. , 2011). o. 8, 30, 300, or 3500 ppm (0, 0. The loci on chromosomes 7 and 8 (Hfhl1 and Hfhl2, respectively) are novel and appear to adversely affect only high frequencies (≥30 kHz). 5 mg of MCA six times a week, and the incidence of respiratory tract SCC was 86% at 10–28 weeks. BLM via OPA (2 IU/kg) was used to induce PF. The main finding in these RI studies was that aspartame caused increased incidence of malignant tumors in multiple organs in rodents. MAC and BAC were not teratogenic to Swiss mice at the doses tested. 5 µg of each of the plasmids pMSV-T24-H-ras and pMSV-c-myc were required for tumor induction. Abstract. In the present study the effect of isolation in other behavioral paradigms and their relation to brain monoamine concentrations were investigated. . used the NIH Swiss strain. N:NIH Swiss outbred mice (albino) were crossed to C57BL/6N (black, non-agouti) mice to generate a hybrid black mouse that was heterozygous for the agouti locus. 1 Nov 28, 2023 · Correction to: 1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice Toxicol Sci . 3. Objective: The aim of this study was to explore the influence of short-term (2-week) exposure to social (SE) and/or physical enrichment (PE) on the anxiety-like behavior of ovariectomized (OVX) NIH Swiss mice. and 4. 01) when compared with paracetamol Nov 11, 2003 · Male Swiss mice, 4–6 weeks old, weighing 20–24 g, were housed in our animal care facility in groups of 3–6 and kept under standard conditions (room temperature of 22–23°C, 12 : 12 light–dark cycle, free access to food and water). We crossed the high frequency hearing loss (HFHL) line of NIH Swiss mice to three different inbred strains and performed linkage analysis on the DPOAE data obtained from the second-generation populations. After a 35 day recovery period, the following The humoral immune responses of NIH Swiss and SWR/J mice immunized with formalin-inactivated AKR or Gross murine leukemia virus, respectively, were examined. The cells were selected for their high cloning efficiencies and low saturation density. FOL was characterized by the replacement of bone marrow by fibrovascular tissue and was first seen at 59 weeks of age, most commonly in the nasal Our extended animal studies suggest that oral administration of silibinin (70mg/kg for 3 days) to mice prior to whole-body gamma-exposure (7. NIH today awarded a set of cooperative agreements totaling more than $110 million to begin the second phase of the Knockout Mouse Project (KOMP). CBD was orally administered to 21-day-old male Swiss mice at doses of 15 and 30 mg kg -1 daily (CBD 15 and 30 groups, respectively), with a control group receiving sunflower oil, for 34 consecutive days. Through a series of test matings and backcrosses (N10) to the N:NIH (S) strain, the agouti gene was A polymerase chain reaction assay revealed that all of the NIH Swiss and Black Swiss mice tested were homozygous for the recessive retinal degeneration 1 mutation of the Pde6b gene. 1093/toxsci/kfad095. Histological examination of NIH Swiss and Black Swiss mouse eyes confirmed the presence of retinal degeneration, which causes visual image blindness. Swiss mice are highly resistant to Leishmania infections in concordance with observed response in humans, while BALB/c mice indicate a high-susceptibility phenotype. Methods: Twenty four mice were divided Animals. 41 g) were used for the experiment. However, neither of them blocked MK801-induced effects, albeit doxycycline had a modest impact against ketamine-induced effects. The effect of hematopoietic stem cell age on leukemogenesis in vitro was tested in nonrecharged, corticosterold-supplemented NIH Swiss [N:NIH(S)] mouse long-term bone marrow cultures infected with Friend murine leukemia virus of anemia-inducing strain (F-MuLV-A) or spleen focus-forming virus (SFFV) … For example, in NIH Swiss strain mice tolerance to caffeine might have been judged to be complete and insurmountable only if doses of 20 or 30 mg/kg or greater were studied (see Fig. Familiarity with the testing arena tended to … Sep 25, 2021 · This study used a six-week-old female SWISS strain Mus musculus divided into three different treatment groups. 1007/BF01922549. 5 ml/dilution, 16 animals per group). With … Over the next five years, National Institutes of Health (NIH)-funded researchers will extensively test and generate data about mice with disrupted genes to gain clues about human diseases. IN SWISS (CD-l@)MICE (MOUSE SKIN STUDY) U. 2 and Panther-GeneGo. In 2005, it was reported that the Black Swiss and NIH Swiss mouse both had visual and cognitive disturbances which was shown to be secondary to homozygous Pde6b rd1 mutation[ 23 ]. The general absence of long-term behavioral Jan 1, 2015 · The lack of robust difference in the time spent in the closed arms and the open arms during EPM might be due to visual deficits caused by the retinal degeneration gene in the background of NIH Swiss mice, since Clapcote and coworkers reported impaired performance by NIH Swiss mice in the Morris water maze, which relies of distal visual cues Germ-free BALB/c and NIH Swiss mice were colonized with microbiota from SPF NIH Swiss or BALB/c mice. Importantly, our animals were older than those in the aforementioned study. Three doses of saf … Oct 8, 2016 · Healthy adult male Swiss-Webster mice (5-7 weeks of age, with average body weight (BW) of 30±2g were used in this study. The frequency of occurrence of neoplasms at different sites was: diaphragm, 45%; rib …. , and Charles River Laboratories, Wilmington, MA) weighing 20 to 25 g on delivery were housed 12 animals per cage in temperature-controlled rooms maintained at an ambient temperature of 22 ± 2°C at 45 to 50% humidity at the University of Michigan, the Yerkes National Primate Research Cent Dec 15, 2015 · The reasons for the discrepancies between our studies are unclear, but they could be related, in part, to differences in experimental design. Methods: Six groups of 62-122 male and female Swiss mice were treated with APM in feed at doses of 32,000, 16,000, 8,000, 2,000, or 0 ppm from prenatal life (12 days of gestation) until death. Jul 7, 2015 · And yet, three weeks after receiving NIH Swiss gut bacteria, the BALB/c mice were quicker to take the plunge. In most animals' species, including man, the kidney is the main site of deposition of inorganic mercury and target organ for its toxicity. FBJ virus was injected i. Black Swiss Mouse Details. 黑色Swiss小鼠（Black Swiss mouse）： 将Carl Hansen博士开发的N:NIH Swiss小鼠（白色Swiss小鼠）与 C57BL/6N（黑色）杂交，通过一系列的交配筛选以及与种鼠（白色Swiss小鼠）回交 (N10) 形成的黑色Swiss小鼠品系。由于野生色基因被消除而成为黑色。 Feb 16, 2012 · Apigenin, a dietary flavonoid, is reported to have several therapeutic effects in different diseases including cancer. Mouse Haplotype Table MHC Class I MHC Class II MHC Class Ib Mouse Strains MHC Haplotype H-2K H-2D H-2L I-A I-E Qa-2 Qa-1 CD45 (Ly-5) Thy-1 (CD90) NK1. In this study, we examined colonization dynamics of segmented filamentous bacteria (SFB) in intestine of Swiss Webster (SW) mice infected with Helicobacter hepaticus (Hh). Mice were tested between 10. 7 g/ml. 0 mg kg-1 b. p. This work standardised and validated a method to register the active and passive behaviours of Swiss mice during the FST in order to strength the specificity of the test. Purpose: To establish a murine model of corneal candidiasis that permits molecular evaluation of fungal adherence and invasion. Western blots were used to measure BDNF and its precursor, pro-BDNF, protein expression in the hippocampus and the frontal cortex of these mice. Mean fetal body weight was reduced at 30 mg/kg/day. In the present study, Apigenin was administered intraperitoneally to Swiss mice Mar 19, 2017 · Male and female Cr:NIH(S) Mice (NIH Swiss) mice were purchased from Charles River at the age of 6-8 weeks and were allowed to age at the RPCI Animal Facility. w. pyrethrum var. Th2/1 cells differentiated from naive precursors and accumulated in spleen and intestine of infected mice, resulting in increased systemic and mucosal IFN-γ production. m. By quantitative trait locus (QTL) mapping, two significant QTLs were identified underlying hearing loss in Black Swiss mice: one QTL mapped to chromosome (chr) 10 (named ahl5, LOD 8. An eightfold increase in circulating micronuclei was also observed. Feb 22, 2021 · Moreover, focal tubular necrosis was observed in the kidneys of mice treated with the roots, seeds, leaves, and capitula of A. It was obtained from a human rhabdomyosarcoma cell (RD) that had been serially transplanted in immunosuppressed NIH Swiss mice, a strain of mouse from which infectious type-C virus has not been isolated. 18, 1. Carl Hansen. They were obtained from Charles River Laboratories, Inc. Mar 15, 1975 · Biological effects of microwave radiation on the testes of Swiss mice. Objective: The aim of this study was to evaluate the carcinogenic effect of sucralose in mice, using a sensitive experimental design. Mar 1, 2022 · The present study evaluated the antiparasitic effect of curcumin extract on Schistosoma mansoni in Swiss albino mice. Dec 1, 2017 · To reveal 1,2-DCE-induced male reproductive toxicity and to elucidate the underlying mechanisms, we exposed male National Institutes of Health Swiss mice to 1,2-DCE by inhalation at 0, 100, 350, and 700 mg/m3 for 6 h/day, for 1 and 4 weeks. 00 p. In contrast, DBA/2 mice that received intratracheal injections of 0. Mar 10, 2023 · BC3F1 mice were injected with 0. Apr 4, 2008 · The only known ligand and agonist of TLR5 is the bacterial protein flagellin ( 17 ). The gross pathology of the tumor-bearing animal rev … Jun 22, 2023 · Objective: This study aimed to determine the effects of soybean (Glycine max) administration on ZP2 expression in female mice. Experientia. The animals were housed in polypropylene cages with a dimension of 430 × 430 × 200 mm, in an environment with the temperature of 23±1°C and a light/dark cycle of 12 h. Methods: Corneas of immunocompetent, methylprednisolone-treated, and cyclophosphamide-treated adult NIH Swiss and BALB/c mice were topically mock inoculated or inoculated with 10-fold increasing amounts between 100 and 100 million colony-forming units (CFU) of Candida Feb 1, 2013 · Female Swiss or RivmN/NIH mice (14–16 g) were immunized ip with a 5-fold dilution series of wP or Plow (0. A concurrent positive control group of dietary 17beta-estradiol (0. Mice, isolated for 0-20 days, w … Mar 29, 2010 · Newborn mice were more sensitive than adults and NIH Swiss mice were more susceptible than C57BL/6 mice 32. However, vascular congestion and lymphoid hyperplasia were observed in the spleens of mice treated with A. Therefore, we selected a non-aversive learning and memory task to determine whether acute TETS intoxication impairs memory in NIH NIH Swiss mice acutely intoxicated with TETS exhibited no significant anxiety-related, depression-relevant, learning or memory deficits relative to vehicle controls at any of the time points assessed with the exception of significantly increased locomotor activity at 2months post-TETS intoxication. Ahl5 and ahl6 account for 61% and 32% of the variation in the We have recently found that, besides an increase in aggression, isolation increases social interaction in NIH Swiss mice. In the first study, ambient temperature was varied between 20 °C and 28 °C in groups of singly housed mice. 2023 Nov 28;196(2):261-262. At death each animal underwent complete Substances. ) and/or diazepam (2 mg/kg, p. Mean measurements ( ± SEM To explore whether aberrant miRNA expression is involved in liver abnormalities mediated by 1,2-DCE exposure, we examined alterations in miRNA expression patterns in the livers of NIH Swiss mice after dynamic inhalation exposure to 350 or 700 mg m-3 1,2-DCE for 28 days. To investigate whether flagellin has in vivo radioprotective activity, we injected flagellin purified from Salmonella enterica serovar Dublin ( 18) into NIH-Swiss mice 30 min before total-body γ irradiation (TBI). However, the efficiency of tumor induction was low: 12. Black Swiss mice are not mentioned in the description of the genetics of the mouse. Analyses of brain damage at 7 days post-exposure by in vivo imaging and histology (FJC The behavior of isolated Cr:NIH(S) mice (Mus musculus) was studied in a holeboard test of exploration, in a plus-maze test of anxiety, in the resident-intruder paradigm of aggression, and in the swim test. Thereafter, mice that were matched for body weight were housed together in groups of 4-5. 9, peak association 35-42 cM) and a second QTL localized to chr 18 (ahl6, LOD 3. Results: Mice were protected from the hepatotoxic action of paracetamol as evidenced by significant reduction in the elevated serum level of ALT (P<0. , Indianapolis, IN) and Swiss-Webster mice (Harlan, Inc. Increasing periods of isolation increased both the total time spent in social interaction and also increased the incidence of aggressive behavior. For example, we used the DBA/2NCrl strain as stimulus mice, whereas in their study Desbonnet et al. Morris water maze probe trial. 03, 0. 001), ALP (P<0. Cetyl myristoleate was isolated from National Institutes of Health, general purpose, Swiss albino mice that were immune to the polyarthritis induced in rats with Freund's adjuvant. We have compared the effect of three different NTCU doses (20, 30, and 40 mmol/L) in female and male of NIH Swiss, Black Swiss, and FVB mice on tumor incidence, survival, and toxicity. The whole plant of Stellaria media (family: Caryophyllaceae) has been tested for its antiobesity activity by using progesterone-induced obesity model in female albino mice. Sesamol (SM) is a dietary phytochemical present in the processed sesame oil. This study aimed to assess the effects of chronic CBD exposure on the male reproductive system. At > or = 10 mg/kg/day, an increased incidence of fetal variations (extra rib) was observed, although fetal malformation rate was unaffected. We found that both minocycline and doxycycline prevented amphetamine-induced prepulse inhibition (PPI) disruption. Sep 28, 2016 · Male Swiss, Webster mice were injected with DM, ketamine, or imipramine and their behaviors were evaluated in the forced-swim test and the open-field test. Developing a cross-breed between BALB/c and Swiss mice may have important consequences on disease development, immune responses and parasite killing, as yet, response of the cross Mice (Mus musculus) have been used extensively as animal models for biomedical research in genetics, oncology, toxicology, and immunology as well as cell and developmental biology. Dec 18, 2020 · Methods: We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss (heterogeneous), BALB/c and C57BL/6 (isogenic), and B6D2F1 (hybrid), totaling 160 mice. oleifera leaves in different behavioral paradigms that evaluate anxiety in mice. 1, 0. 0 mg/kg body weight) induced toxicity led to significant elevation of lipid peroxidation (LPO) level but decline in the glutathione content in liver of Swiss albino mice. However, NTCU induces lung cancer with variable efficacy and toxicity depending on the mouse strain. Chronic ingestion of caffeine by male NIH Swiss strain mice leads in about 3 days to a significant increase in A 1 -adenosine, nicotinic and muscarinic receptors, and a significant decrease of 1 -adrenoceptors in cerebral cortical membranes. Nov 11, 2017 · NIH 3T3 cells are a clonal line of mouse embryo fibroblasts derived from randomly bred Swiss mice . Because tumor induction required that a single cell take up both plasmids, it was In these studies, adult male NIH Swiss mice were surgically implanted with radiotelemetry probes that simultaneously monitored core temperature and locomotor activity across various housing conditions. Behavior was evaluated using step-down and light preference tests. Here, we demonstrate Th2/1 cells as the major source of parasite-specific IFN-γ production in acute and chronic infections with the enteric nematode Heligmosomoides polygyrus. The present study is designed to develop oropharyngeal aspiration (OPA) model of bleomycin (BLM)-induced PF as a simple and alternative to intratracheal (IT) administration of BLM in Swiss mice strain. Jun 24, 2009 · Healthy Swiss albino mice (male and female mice, 15–20 g weight) were divided into four groups (three treatment groups and one control group). To fully explore the mechanism of 1,2-DCE-induced hepatic abnormalities, 30 male National Institutes of Health (NIH) Swiss mice were exposed to 0, 350, or 700mg/m 3 of 1,2-DCE, via inhalation, 6h/day for 28days. 5 mg of MCA four times a week resulted in 6% incidence of SCC of the respiratory tract at 7 months ( 43 ). Dec 31, 2018 · Methods: Retinas from eight male and eight female 30-week-old outbred ND4 Swiss Webster mice were harvested and immediately processed for MS analysis on a Thermo Fisher (TF) Fusion Orbitrap MS. Analysis were standardized using the systems pocH-100iV Diff ™ for 19 hematological parameters and VITROS ® 350 for 12 biochemical parameters. ) on cisplatin (CIS), cyclophosphamide (CPH), mitomycin-C (MMC) and urethane (URE) induced alterations in lipid peroxidation and antioxidant status were investigated in Swiss albino mice. Interpretation of the marked left shift of the caffeine dose–response curve suggests that the pathways underlying the stimulatory effects of caffeine are Forty albino male mice of the Swiss strain, weighing between 25 and 30 g, from the colony of creation of the vivarium, were used. The antioxidant properties of SM were evaluated by using different … A B-cell lymphoma was induced in athymic NIH Swiss nu/nu mice by challenging the animals with NIH3T3 cells, previously transfected with a recombinant DNA carrying a human oncogene hhcM, ligated to an SV40 promoter with a neomycin-resistance marker. In the present study Spirulina fusiformis (a cyanobacterium, belongs to family--Oscillatoriaceae) has been investigated as a possible modifier of mercury induced renal damages in Swiss albino mice. v. into the tail vein of a NIH/Swiss mouse produced a local metastatic tumor near the base of the tail from which the T2-A cell line was established. Forty Swiss mice (n = 10/group) of either sex were given distilled water (10 mL/kg) and graded doses of EEGL (100, 200, and 400 mg/kg) orally for 30 days, during which feed and water intake, body weight, neurobehavioral, and safety data were documented. 018, 0. Jan 12, 2000 · Lymphomas were induced in NIH Swiss mice infected as neonates with tissue culture-propagated MuLVs isolated from normal and tumor tissue of CFW mice. Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Developed at the NIH Genetic Resource by Dr. Jan 1, 2016 · These GhrasT-NIH/Swiss cells were injected s. This warrants dose-specific evaluation of toxicity in vivo. Apr 27, 2012 · Here we used 2f1-f2 distortion product otoacoustic emissions (DPOAE) measurements to refine the hearing loss phenotype. Oct 23, 2014 · NIH Swiss or Swiss Webster outbred mice have been utilized to demonstrate differences in neuroinvasiveness and neurovirulence between naturally occurring and engineered WNV strains , to study molecular determinants of neuroinvasiveness in related lineage 1 WNV strains , and for evaluation of candidate vaccines and therapeutics –. After weaning at 21 days, 16 female offspring were maintained on a regular chow diet, Purina 5001 (Purina), until they were 30 days of age and then randomly assigned to two groups of eight, and fed either the LF or VHF diets (Research Diets, New Brunswick, NJ; Table Table1) 1 Oct 28, 2020 · Aim of the study: The aim of this study was to evaluate the action of the hydroalcoholic extract from the roots of Pfaffia glomerata on the Leydig cells, cavernous bodies and other penile constituents, as well as on serum testosterone and 17β-estradiol levels of adult mice. into NIH/Swiss mice to produce primary tumors from which one was used to establish the T1-A cell line. The mean latent period of the tumors was 71 days (26 to 145) postinjection. c. Mice homozygous for NIH Swiss alleles at either Hfhl1 or Hfhl2 have 32-kHz auditory-evoked brain stem response thresholds that are 8-14 dB SPL higher than the corresponding heterozygotes. This substance, or material synthesized from cetyl alcohol and myristoleic acid, afforded good protection against adjuvant-induced arthritic states in rats. pyrethrum extracts excluding the root extract (APPC). The soybeans given are in the form of whole beans. The main findings in this study are: (1) NIH Swiss mice present with a higher incidence of SCC and lower mortality and toxicity compared with Black Swiss and FVB mice; (2) 30 mM NTCU dose induces SCC at the same rate and incidence than the 40 mM dose with lower toxicity and mortality in treated mice; (3) female mice present higher grade and Relative to C57BL/6J mice, the NIH Swiss mice exhibited significantly decreased pain sensitivity (Supplementary Figure 2), which may explain the poor response of the NIH Swiss mice in contextual fear conditioning. Additional studies held the mice The social behavior of pairs of male NIH Swiss mice was assessed under a variety of experimental conditions. Methods: This research used Mus musculus, six-week-old female SWISS strain mice divided into three groups (group without soybean administration and groups with mixed feed with soybeans and pelleted 50:50 and 25:75). We also test a mechanistic hypothesis that 1,2-DCE inhibits cAMP-response element modulator (CREM)/cAMP-response element binding protein (CREB) signaling cascade and subsequently induces apoptosis. Feeding treatment was carried out for 2 weeks. Excessive exposure to 1,2-Dichloroethane (1,2-DCE), a chlorinated organic toxicant, can lead to liver dysfunction. In this present study, administration of PFUnA for 28 days with five doses (0. The mice were kept under the average husbandry environment with a 12 h light-dark cycle (8 : 00 to 20 : 00) for two weeks to acclimate with the laboratory environment. doi: 10. (Wilmington, MA, USA) and allowed to acclimate for 10 days before treatment. during the light phase. The retinal proteome and phosphoproteome were identified and subsequently analyzed using Proteome Discoverer 2. Treatment-related changes included decreases in circulating erythrocytes, total hemoglobin, and hematocrit and an increase in mean corpuscular volume. They were provided by the Ho Chi Minh City Pasteur Institute (Ho Chi Minh City, Vietnam). T1-A cells injected i. Male NIH Swiss mice (Harlan, Inc. In this present study we have evaluated the antioxidant potential of SM and its role in the protection of radiation-induced DNA damage in γ-irradiated mice. 1975 Mar 15;31 (3):301-2. 5 ppm; 28 per sex) confirmed the sensitivity of CD-1 mice to an endogenous The antipsychotic-like effect of doxycycline, a minocycline analog, was investigated here. 1973 Nov;33 (11):2768-73. Objective: The aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice. 01) and an increased level of total protein (P<0. Each group consists of 6 male and 6 female animals. Jun 25, 2020 · This study investigated the anxiolytic-like effects of crude organic fractions of M. 3, 5, 50, or 600 mg BPA/kg/day, 28 per sex per group). 003, 0. media on food consumption pattern, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad. In the first experiment, 8- to 10-wk-old NIH Swiss mice (Harlan, Madison, WI) were bred to stud males. At 8 weeks post-inoculation with Hh (WPI), cecal and colonic SFB levels in the control males were significantly lower compared to those at 16 WPI. DEPARTMENT OF HEkLTH AND HUMAN SERVICES Public Health Service in NIH-07 Rat and Mouse Ration Jun 1, 2023 · The mushroom was identified and authenticated via techniques of molecular biology. 001), total bilirubin (P<0. zo io wj an fs ww ba me eh vi