Ergometrine drugbank. Type Small Molecule Groups Ergonovine.

An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties. 1 All these components are produced by the fungus Claviceps purpurea and are all derivatives of the tetracyclic compound 6-methylergonovine. 1960. The plasma protein binding of ergometrine is unknown. The content on the NICE BNF site (BNF) is the copyright of BMJ Publishing Group Ltd and the Royal Pharmaceutical Society of Great Britain. Generic Name Misoprostol DrugBank Accession Number DB00929 Background. The components are synthetically produced oxytocin, a human hormone produced in the hypothalamus, and ergometrine, an alpha-adrenergic, dopaminergic and serotonin (5-HT 2) receptor agonist. Clinical intelligence tool for your Naratriptan is a 5-HT1B/1D receptor agonist used to treat migraines. com to check out our commercial products, use cases and more! DrugBank For Clinical Software. They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). Carboprost is a synthetic prostaglandin. Reboxetine is primarily used to treat depression but has also been found useful in the treatment of narcolepsy and panic disorders. Ergometrine maleate / Ergonovine maleate UNII YMH3D0ZJWV CAS Number 129-51-1 Weight Average: 441. Sep 19, 2023 · Ergometrine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. Metergoline: An ergot-derivative that acts as an antagonist at certain 5-HT receptor subtypes and as an agonist at dopamine receptors. Structured drug data for data 11979741. Ergometrine cũng gây co mạch, chủ yếu các tĩnh mạch, gây tăng áp lực tĩnh mạch trung tâm, tăng huyết áp. Ipratropium is a quaternary ammonium derivative of atropine 4 that acts as an anticholinergic agent. Comment: Ergometrine is an ergot alkaloid which causes contraction of uterine and vascular smooth muscle cells acting through a variety of GPCRs (such as adrenoceptors, dopamine receptors, and 5-HT Jun 13, 2005 · It acts by increasing the force of the heart's pumping action as well as constricting peripheral blood vessels. x, 15:2, (333-344), Online publication date: 1-Jun-1960. Buspirone. Xylometazoline is an imidazoline derivative 4 with sympathomimetic and nasal decongestant activity. DB14895. Agomelatine was developed in Europe by Servier Laboratories Ltd. Panectyl. Vitamin K1 is a fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses. An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Clinical API. 0000 o 0 0 0 0 0 0 0 0 0 0 0 0 1. 1 Dec 6, 2019 · Ergometrine. Generic Name Lumateperone DrugBank Accession Number DB06077 Background. Aquamephyton, Infuvite, Infuvite Pediatric, Mephyton, Mvi Pediatric, Phytonadione. Metaraminol. Ergometrine, also known as ergonovine and sold under the brand names Ergotrate, Ergostat, and Syntometrine among others, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. Ergotamine: Ergotamine may increase the hypertensive and vasoconstricting activities of Racephedrine. Summary. Ergometrine. DrugBank For Clinical Software. 15 It is one of the most commonly prescribed anticholinergic medications. Administration of midodrine results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension GtoPdb Ligand ID: 148. Ergometrine and oxytocin differ in their actions on the uterus. , the therapeutic effect of orally administered midodrine is due to the major metabolite desglymidodrine formed by deglycination of midodrine. 2. Ergotamine Jun 1, 2023 · The molecular formula of ergometrine maleate, designated chemically as 9,10-didehydro -N- [ (S) -2-hydroxy-1-methylethyl]-6-methylergoline-8-carboxamide hydrogen maleate is C 19 H 23 N 3 O 2 ,C 4 H 4 O 4. DrugBank Accession Number DB00871 Background. Ergometrine maleate / Ergonovine maleate UNII YMH3D0ZJWV CAS Number 129-51-1 Jun 13, 2005 · Reboxetine is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class. Xylometazoline works by binding to alpha (α)-adrenergic receptors to cause vasoconstriction of nasal blood vessels. It is an agonist of α1A, partial agonist of α1B and α1D, and a nonselective antagonist of α2. Accession Number. Jun 13, 2005 · DrugBank Accession Number DB00036 Background. Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. 11 It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients. Absorption. Ipratropium. Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Though it is widely used, its mechanism of action is still unknown Label 1,3,4,6. Magnesium sulfate. 04 L/kg. Jun 10, 2014 · Etilefrine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy. It is an α-adrenoceptor and dopamine receptor agonist and acts almost immediately when injected intravenously. Doxofylline. Lithium has been used to treat manic episodes since the 19th century 3. Cirazoline acts on a number of α adrenergic receptors. 麦角新碱 （英語： Ergometrine 或ergonovine），又名 D-麦角酸β-氨基丙醇, 是一类用于引起 子宫 收缩来治疗阴道 产后出血 的药物。. 1062 0. Midodrine is a prodrug, i. Oliceridine. A 9,10alpha-dihydro derivative of ergotamine. The uterus is stimulated at all times, but is much more sensitive in late pregnancy (see also ergotamine, p. Clonidine was granted FDA approval on 3 September 1974. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus. and submitted to the European Medicines Agency (EMA) in 2005. Alkaloids originally isolated from the ergot fungus Claviceps purpurea (Hypocreaceae). Ondansetron. Jun 13, 2005 · Learn more. Generic Name Cisatracurium DrugBank Accession Number DB00565 Background. DB00653. 1111/j. 15. Bupivacaine. Type Small Molecule Groups Dexamethasone is a powerful anti-inflammatory drug that can be used for various conditions, such as asthma, endocrine disorders, and rheumatic diseases. 4 DrugBank Accession Number DB09214 Background. Train your ML models with ground truth data. 8,9,10 Lisinopril is not a prodrug, and functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system. As a drug used in the treatment of asthma, doxofylline Navigate to DrugBank. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it Feb 25, 2016 · Tylosin is a bacteriostatic macrolide antibiotic and feed additive used in veterinary medicine. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. A long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Iofetamine I-123. The introduction of a transnasal formulation of butorphanol represents a new and noninvasive presentation of an analgesic for moderate to severe pain. Type. Type Small Molecule Navigate to DrugBank. Type Small Molecule Groups Ergonovine. Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade. 5,7 It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Jun 13, 2005 · Butorphanol is a synthetic opioid agonist-antagonist analgesic with a pharmacological and therapeutic profile that has been well established since its launch as a parenteral formulation in 1978. Simplify data normalization from multiple sources with comprehensive lists of synonyms, brand names, code names, & other common identifiers. Generic Name Triamterene DrugBank Accession Number DB00384 Background. Methylergometrine: An ergot alkaloid used to prevent and control uterine atony and hemorrhage before and after delivery. DB00320. 6 It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. Ergomar, Migergot. Visit DrugBank. 1476-5381. Structured drug data for data Ergometrine: An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. 3,4,5 It has a wide therapeutic index and a long duration of action as patients are generally given Generic Name Glycopyrronium DrugBank Accession Number DB00986 Background. Explore detailed drug information packages to support your research & drug discovery. KARP D, RINZLER S and TRAVELL J (2012) EFFECTS OF ERGOMETRINE (ERGONOVINE) ON THE ISOLATED ATHEROSCLEROTIC HEART OF THE CHOLESTEROL-FED RABBIT, British Journal of Pharmacology and Chemotherapy, 10. Thuốc được coi là có tác dụng co cơ trơn thông qua hoạt tính hỗn Jun 13, 2005 · With the clinical doses of carboprost tromethamine used for the termination of pregnancy, some patients do experience temperature increases. It is concluded that ergometrine causes direct activation of postsynaptic alpha 1-adrenoceptors, and it is suggested that it acts on the same subtype of the receptor as imidazoline agonists. Dale first identified oxytocin and its uterine contractile properties in 1906. com to check out our commercial products, use cases and more! DrugBank For Commercial Research. Xylometazoline is available in over-the-counter (OTC) nasal sprays or drops to temporarily relieve nasal congestion due to An alpha-1 adrenergic agonist used in the management of hypotension, generally in the surgical setting associated with the use of anesthetics. G02 — OTHER GYNECOLOGICALS. 6 Vibegron was first approved in Japan in September 2018 for the treatment of overactive bladder, 1 a condition associated Navigate to DrugBank. 2215 0. [1] 它可用于口服，肌肉注射或 静脉注射 。. Drug Datasets. 297). It binds the prostaglandin E2 receptor, causing myometrial Dec 2, 2015 · DrugBank Accession Number DB00184 Background. Ergoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. DB13885: Ferric subsulfate Ergotamine is an alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. 8. Cirazoline. Clinical intelligence tool for your 1253 mrv0541 02231215212d 25 28 0 0 1 0 999 v2000 2. Dexketoprofen is a non-steroidal anti-inflammatory drug. com to check out our commercial products, Ergometrine Versus Oxytocin in the Management of Atonic Post-partum Haemorrhage (PPH) in Women DrugBank Accession Number DB14509 Background. Visit DrugBank Online to get more information about dexamethasone and other drugs. 13,7 In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist With phenoxybenzamine as antagonist, the estimated dissociation constant (KD) for ergometrine was 0. Harness our meticulously curated biomedical knowledgebase, designed specifically for pharmaceutical research. The risk or severity of methemoglobinemia can be increased when Tylvalosin is combined with Bupivacaine. The latent period for occurrence of the uterine response is about 7 minutes. DB00696. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. Brand Names. Dihydroergotamine. By using BNF, you agree to the licence set out in the BNF Publications End User Licence Agreement. ATC Classification. G02A — UTEROTONICS. 8,9,10,11. DBCAT000606 (DBCAT002711) Description. 1 Diazoxide is commonly used in the treatment of hyperinsulinaemic Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. DB13885: Ferric subsulfate Generic Name Diazoxide DrugBank Accession Number DB01119 Background. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Quick Links Dose Administration Monitoring Pregnancy and Breastfeeding Restrictions Formulary: Unrestricted Medication Class Oxytocic Presentation Ampoule: 500microg/1mL Storage Store at 2 to 8°C. drugbank. Zotepine activities are also related to the inhibition of noradrenaline reuptake and serotonergic activity. 13,7,20 Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. Terbutaline was granted FDA approval on 25 March 1974. A vasoconstrictor found in ergot of Central Europe. Access structured, in-depth information & broaden your research. com A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Generic Name. 2213 0. Small Molecule. Oxymetazoline. Metaraminol acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic). Nicotine is also important medically because of its presence in tobacco smoke. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. Methyldopa. Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. DB09273. Type Small Molecule Groups Approved Structure Jun 30, 2007 · Josamycin is a macrolide antibiotic from Streptomyces narbonensis. 15 They are both quaternary ammonium compounds and long acting muscarinic antagonists. DB01022. Flupentixol Mar 19, 2008 · Agomelatine is structurally closely related to melatonin. The Department of Health and Aged Care acknowledges First Nations peoples as the Traditional Owners of Country throughout Australia, and their continuing connection to land, sea and community. Ergometrine Scope (Staff): All WNHS Staff Scope (Area): Obstetrics and Gynaecology This document should be read in conjunction with the Disclaimer. Many of the ergot alkaloids act as alpha-adrenergic antagonists. View ergometrine maleate information, including dose, uses, side-effects, renal May 17, 2007 · DrugBank Accession Number DB01282 Background. Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form, cisatracurium besylate. Distribution. Ergotamine. Sep 18, 2020 · Pharmacodynamics. Terbutaline was first synthesized in 1966 12 and described in the literature in the late 1960s and early 1970s. 2 This activity is useful for the treatment of hypertension, severe pain, and ADHD. The risk or severity of hypertension can be increased when Etilefrine is combined with Iofetamine I-123. See full list on go. An ergot-derivative that acts as an antagonist at Ergometrine: An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Naratriptan is a triptan drug that is selective for the 5-hydroxytryptamine1 receptor subtype. DB00952. Alimemazine. Vibegron is a potent, selective beta-3 adrenergic receptor (β3) agonist that relaxes the detrusor smooth muscle of the bladder, thereby increasing bladder capacity. (verify) Oxytocin/ergometrine (trade name Syntometrine) is an obstetric combination drug. An alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea. Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels. 484 Monoisotopic: 441. e. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions. DB01246. 6520 3. DrugBank Data that Cites this Article Drug Feb 26, 2016 · The serum concentration of Budesonide can be increased when it is combined with Tylvalosin. Structured drug data for data Ergot Alkaloids and Derivatives. It has analgesic, antipyretic and anti-inflammatory properties 2. Alimemazine is an antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria. Controlled substance for Ergometrine. Ergometrine: Uses, Interactions, Mechanism of Action | DrugBank Online / Pharmacological properties of Datura stramonium L as a potential medicinal tree: An overview. NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Type Small Molecule Groups Approved, Investigational Structure DrugBank Accession Number DB00575 Background. Esmolol is a cardioselective beta-adrenergic blocker used for the short-term control of ventricular rate and heart rate in various types of tachycardia, including perioperative tachycardia and hypertension. com to check out our commercial products, use cases and more! Ergometrine làm tăng biên độ, tần suất co tử cung, tăng trương lực cơ tử cung nên làm giảm chảy máu. com for detailed drug and target data for your pharmaceutical research. Doxofylline is a methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms. Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions. Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol. In some patients, carboprost tromethamine may cause transient bronchoconstriction. . ergometrine is an approved drug. Generic Name Oxycodone DrugBank Accession Number DB00497 Background. DB13483: Etamsylate: A hemostatic agent that acts by restoring capillary resistance and improving platelet adhesion. 7 The derivatives of Vibegron. Build predictive models with a huge range of data features. Ergometrine is an ergot alkoid used for the treatment of postpartum haemorrhage and post procure hemorrhage in patients with uterine atony. 12,16,17. Metergoline. 8 For AI-powered drug discovery & repurposing, our datasets dramatically reduce the time & money it takes to get started, so you can successfully bring a drug or treatment to trial. The average steady state volume of distribution of ergometrine in healthy man is reported to be 1. Navigate to DrugBank. 7 Although there are several antipsychotics including aripiprazole, paliperidone and clozapine available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. It is typically used for the treatment of migraine headaches. Identify potential patterns by grouping drugs based on structural similarity, sequence similarity, type of drug or chemical Mar 5, 2019 · Ergometrine: Ergometrine may increase the hypertensive and vasoconstricting activities of Racephedrine. Dihydroergotamine is an ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. DB04845. By inhibiting norepinephrine production, blood pressure is further reduced. 2,3. 口服15分钟起效，注射则更快。. The metabolism of Buspirone can be decreased when combined with Tylvalosin. Generic Name Gabapentin DrugBank Accession Number DB00996 Background. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects Label. Oct 22, 2015 · Mechanism of action. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity. Ergometrine is absorbed rapidly after IM injection. 2917 0. Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid that was first approved for use in the United States in 1993. Type Small Molecule Groups Approved, Investigational Structure Oct 21, 2016 · The risk or severity of CNS depression can be increased when Olanzapine is combined with Benperidol. Description. Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. 3776 0. Compound class: Synthetic organic. 1 It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. tb01253. Nicotine is highly toxic alkaloid. Its main avenue of effect is reduction in appetite. Reboxetine is an a-ariloxybenzyl derivative of morpholine. 药效持续45到180分钟。. DrugBank Accession Number DB00332 Background. Naratriptan. [1] 常见副作用包括 血压升高 Ergometrine with oxytocin. Sir Henry H. 41 microM. 16 It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures 14,5 - today it is also widely used to treat neuropathic pain. Go from concept to market with precision. Enhance your data pool with structured information. Mechanism of action. com to check out our commercial products, use cases and more! Ergometrine (DB01253) Oxytocin (DB00107) Stay up-to-date with the Generic Name Oxytocin DrugBank Accession Number DB00107 Background. It is available in the various countries in Europe, Asia and Latin America. 189985601 Navigate to DrugBank. Magnesium sulfate is a drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. An alpha adrenergic agonist used to treat hypotension. It performs 2 actions on the renin angiotensin system. Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. Leverage extensive data features for advanced predictive analytics. Nov 6, 2019 · Ergometrine is recommended by the Royal College of Obstetricians and Gynaecologists (RCOG) in second‐line pharmacological management of postpartum hemorrhage due to uterine atony1 after first‐line administration of oxytocin (Syntocinon). Ergometrine is an ergot alkaloid used for the treatment of postpartum weeping and post abortion hemorrhages is patients with uterine atony. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. 0000 n Feb 14, 2008 · Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Lisinopril is an angiotensin converting enzyme inhibitor used to treat hypertension, heart failure, and myocardial infarction. Jun 13, 2005 · Ritodrine is beta-2 adrenergic agonist. The mechanism of action of macrolides such as Josamycin is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby Pharmacodynamics. Synonyms: ergonovine | Ergotrate® | Methergine®. Zotepine is a dopamine antagonist that has a high affinity for D1- and D2-like receptors. is used to contract the uterus. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. DBL Ergometrine Injection consists of ergometrine maleate BP and maleic acid BP in water for injections BP. For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage. It presents a strong antagonism for several serotonin receptors, such as 5-HT2a, 5-HT2c, 5-HT6 and 5-HT7. Methoxamine. It is often used in situations where inhibition of prolactin is desirable. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Leverage 16,885 drugs & associated identifiers, including chemical structures. Phylloquinone Commonly known or available as Vitamin K1. The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Benperidol is combined with Oliceridine. 13,14,4,2,10 The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the DrugBank Accession Number DB01221 Background. Both substances cause the uterus to contract. G — GENITO URINARY SYSTEM AND SEX HORMONES. 0000 o 0 0 0 0 0 0 0 0 0 0 0 0 5. Tylosin is produced as a fermentation product of Streptomyces fradiae. Boost machine learning accuracy with verified ground truth data. Esmolol: The therapeutic efficacy of Racephedrine can be decreased when used in combination with Esmolol. Structured drug data for data Navigate to DrugBank. The drug has antimicrobial activity against a wide spectrum of pathogens. DBCAT000781. 1,2 Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care. It is an inverse agonist for the cannabinoid receptor CB1. Jun 13, 2005 · Generic Name Ergoloid mesylate DrugBank Accession Number DB01049 Background. Background. Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. DrugBank Accession Number. Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in position 7. Ergometrine: Uses, Interactions, Mechanism of Action | DrugBank Online - Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development. Dhe-45, Migranal, Trudhesa. Learn how it works, what are its interactions, and how it differs from other drugs in the same class, such as remifentanil, ellagic acid, and valbenazine. 3 It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period. 2,3 Early research into glycopyrronium use was for its Ergometrine. Ergometrine: An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. cx qm bp du lv gr ch bs fn ba